Student Work

Determining the roles of Candida albicans secreted aspartyl proteases (SAPs) and macrophage pattern recognition receptors (PRRs) in host-pathogen interactions

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Candida albicans is a fungal pathogen that causes opportunistic infections. Host immune cells use pattern-recognition receptors (PRRs) to recognize yeast. However, C. albicans may survive phagocytosis using virulence factors including secreted aspartyl proteases (SAPs). This project explored the roles of host PRRs and yeast SAPs in macrophages. The mannose receptor was found to play a prominent role in yeast recognition and C. albicans SAP knockouts exhibited decreased survival. These data can be used to inform the design of novel antifungals.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
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Identifier
  • E-project-042617-231345
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Year
  • 2017
Date created
  • 2017-04-26
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Last modified
  • 2023-01-20

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Permanent link to this page: https://digital.wpi.edu/show/c534fq536