Faculty Advisor

Rao, Reeta Prusty

Abstract

Candida albicans is a fungal pathogen that causes opportunistic infections. Host immune cells use pattern-recognition receptors (PRRs) to recognize yeast. However, C. albicans may survive phagocytosis using virulence factors including secreted aspartyl proteases (SAPs). This project explored the roles of host PRRs and yeast SAPs in macrophages. The mannose receptor was found to play a prominent role in yeast recognition and C. albicans SAP knockouts exhibited decreased survival. These data can be used to inform the design of novel antifungals.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2017

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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