Faculty Advisor

Dempski, Robert E.

Faculty Advisor

Rao, Reeta Prusty

Abstract

Candida albicans is one of the most common fungal pathogens associated with opportunistic and nosocomial infections. Infection is often initiated through formation of a biofilm, which is also drug resistant. A recently discovered small molecule called filastatin shows some promise as an inhibitor of biofilm formation and adhesion to polystyrene. A high-throughput screening assay was performed using a deletion mutant library in order to determine the functional pathway of filastatin. Results indicate that our drug may play a role in disrupting the iron metabolism pathway, particularly through genes regulated through Hap43 and Rim101.

Publisher

Worcester Polytechnic Institute

Date Accepted

May 2014

Major

Biology and Biotechnology

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Chemistry and Biochemistry

Advisor Department

Biology and Biotechnology

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