Faculty Advisor

Buckholt, Michael Allan

Faculty Advisor

Politz, Samuel M.

Abstract

Candidiasis is a serious disease caused by Candida albicans that affects over four billion people a year. Of those infected, 32,000 of them develop systemic infections in the US with a 30%-60% fatality rate. This type of infection is especially prevalent in immune-compromised individuals such as HIV-infected, diabetes and cancer patients. In this study, we mutagenized Caenorhabditis elegans and exposed them to C. albicans in order to isolate mutants resistant to the yeast infection. After survival tests of mutant C. elegans on C. albicans-containing media, three putative resistant strains were isolated for future analysis. Further characterization of these mutants may identify genes required for sensitivity to C. albicans infections and be useful in the study and prevention of Candidiasis.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2013

Major

Biology and Biotechnology

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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