Faculty Advisor

Buckholt, Michael Allan

Faculty Advisor

Politz, Samuel M.

Abstract

Candidiasis is an invasive and potentially life-threatening health condition that can be triggered by Candida Albicans infection in immunocompromised individuals. The significant increase in incidence of Candidiasis of recent years and currently ineffective drug treatments have motivated research into the genetics underlying Candida infection and host immune responses. To identify gene mutations that may confer resistance to C. albicans, we utilized the nematode C. elegans as a host model due to its ease of use in lab and its susceptibility to Candida infection. Our resistance screens isolated 2 putative mutants that displayed consistently healthy phenotype, movement, and production of offspring when exposed to the yeast over a period of several days.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2012

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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