Faculty Advisor

Adams, David S.

Center

UMMC / University of Massachusetts Medical Center

Abstract

Caused by the spirochete B. burgdorferi, Lyme disease (LD) is the most common vector-borne infection in the United States. In this study, we aim to determine the role of iNKT cells in developing a protective immune response to LD and against Lyme arthritis 4 weeks after infection by studying CD1d-/- (iNKT-deficient) mice. ELISA, qPCR, and clinical rating guidelines to visually score arthritis in the joint were utilized to determine the role of iNKT cells in these mice versus wild-type mice 4 weeks post B.b. infection. Although iNKT cells have been found to control infection 1-2 weeks post infection in other studies, we found that after 4 weeks, iNKT cells do not play a significant role in controlling LD in the murine model used.

Publisher

Worcester Polytechnic Institute

Date Accepted

January 2012

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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