Cell fate determination relies on precise regulation of gene expression. Musashi RNA-binding proteins regulate mRNA targets of neural and epithelial stem and progenitor cells, and Musashi1 expression is correlated with malignancy and proliferation in neural and epithelial tumors. Musashi1 RNA-binding activity is inhibited by a small molecule metabolite through an unknown mechanism. The current study investigates differences in RNA binding and inhibition of four Musashi1 homologs from diverse species.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Johnson, Emily Stratford

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042513-113219

Advisor

• Duffy, Joseph B.
• Heilman, Destin

Year

• 2013

Sponsor

• University of Massachusetts Medical School

Date created

• 2013-04-25

Resource type

• Major Qualifying Project

Major

• Biochemistry
• Biology & Biotechnology

Rights statement

• In Copyright