Faculty Advisor

Duffy, Joseph B.

Faculty Advisor

Heilman, Destin

Abstract

Cell fate determination relies on precise regulation of gene expression. Musashi RNA-binding proteins regulate mRNA targets of neural and epithelial stem and progenitor cells, and Musashi1 expression is correlated with malignancy and proliferation in neural and epithelial tumors. Musashi1 RNA-binding activity is inhibited by a small molecule metabolite through an unknown mechanism. The current study investigates differences in RNA binding and inhibition of four Musashi1 homologs from diverse species.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2013

Major

Biology and Biotechnology

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

Advisor Department

Chemistry and Biochemistry

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