UMass Medical School
Throughout human history, people have been plagued by inflammation. Marijuana has been documented numerous times in recorded history for its ability to alleviate the symptoms of inflammation. The endocannabinoid N-arachidonyl-glycine (NAGly) has been shown induce the resolution of inflammation. In this project, chiral analogs of NAGly were synthesized and screened for anti-inflammatory effects. The results confirmed the stereo-selectivity, previously noted by Burstein and colleagues, favoring the D-isomers over the L-isomers. Therefore, further research projects seeking to design new pharmaceuticals should develop larger drug libraries of elmiric acids focusing on the D-isomers.
Worcester Polytechnic Institute
Major Qualifying Project
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Chemistry and Biochemistry