Faculty Advisor

Rolle, Marsha W.

Abstract

Tissue engineered blood vessels have the potential to address a clinical need for blood vessel replacements. The Rolle lab at WPI developed a method for growing smooth muscle cell tissue rings and then fusing these rings together to form tubular vessel replacements. The goal of this project is to exert control over the aggregation process of the SMCs used to form the ring. An adhesion system consisting of gelatin microparticles was designed to improve aggregation of the SMCs into ring constructs. Testing showed that the gelatin microparticles can be consistently created at an appropriate size and these particles do not harm the SMCs when cultured together. Subsequent tests showed that the microparticles did not inhibit the aggregation speed of the tissue rings.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2012

Major

Biomedical Engineering

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biomedical Engineering

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