Faculty Advisor

Politz, Samuel M.

Abstract

Tissue-specific RNA interference was performed on the model organism Caenorhabditis elegans to cause the knockdown of bli-3, which is hypothesized to play an important role in immune defense through the production of reactive oxygen species. Survival assays on C. elegans infected by the pathogenic yeast Candida albicans revealed highly significant effects on the survival of the worms when the gene was knocked down in the hypodermal and intestinal tissues. There was no significant effect on the survival of worms with bli-3 knockdown in body wall muscle.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2012

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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