Faculty Advisor

Brodeur, Drew R

Center

UMMC / University of Massachusetts Medical Center

Abstract

Traditional contrast agents use inorganic compounds containing metal ions to differentiate tissue types in medical diagnostic imaging. These compounds suffer from toxicity and they do not target specific tissues. A human serum albumin and gold complex (Au@HSA) was synthesized via a biomineralization reaction to overcome these obstacles and the resulting compound was optically active, giving it potential as a contrast agent. Additionally, the Au@HSA was conjugated with the tumor targeting compound arginylglycylaspartic acid without losing its optical activity.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2017

Major

Chemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Chemistry and Biochemistry

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