Faculty Advisor

Billiar, Kristen

Abstract

Cells respond to mechanical stimuli, such as stiffness and stretch, in their environment as shown by changes in phenotype, proliferation, and alignment. We have developed the first method to simultaneously apply stiffness and stretch to a cellular environment using the Flexercell stretching device and the stiffness-tuneable hydrogel, polyacrylamide. Functionality and cell viability were verified and measurements of mechanical stimuli were validated. This method will be applied in future research to study heart valve cell mechanobiology in normal and diseased states.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2007

Major

Biomedical Engineering

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biomedical Engineering

Your accessibility may vary due to other restrictions.

Share

COinS