Faculty Advisor

Ryder, Elizabeth F

Abstract

Transcription Cofactors (TCFs) are essential non-DNA binding gene expression regulatory proteins. 162 TCFs were predicted within C. elegans using literature search and BLAST. Predicted TCFs consist of mediators, TAFs, nucleosome remodeling, modification, and tail binding proteins. Using a proprietary PSI-MI2.5 parser, 98 known interactions were queried with only 9 interactions with predicted Transcription factors (TFs). 45.7% predicted TCFs shows cause embryonic lethality from RNAi phenotypes. The predicted TCFs can be experimented with predict TFs to find novel interactions.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2010

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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