Arguello, Jose' M.
Transition metal homeostasis is important for organisms, as they are both essential for biological processes as well as toxic. The opportunistic parasite Pseudomonas aeruginosa has shown that metal ion homeostasis, specifically copper, may be important to its pathogenesis. This study utilizes the nematode Caenorhabditis elegans as a model organism to study this pathogenesis. C. elegans was exposed to mutants of P. aeruginosa that pertain to the bacterias copper homeostasis system and lethality was measured over time to infer the importance of these genes to P. aeruginosas pathogenesis. Here, it is shown that knockouts of these genes do cause a decrease in lethality, suggesting copper homeostasis is an important measure by which P. aeruginosa resists the immune responses of its hosts.
Worcester Polytechnic Institute
Major Qualifying Project
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Chemistry and Biochemistry