Faculty Advisor

Duffy, Joseph B

Abstract

Cellular adhesion is an essential factor in development, serving both structural and communicatory functions, defects in which have been implicated in a wide range of diseases, including cardiovascular and neurodegenerative disorders. Kekkon5, a transmembrane protein in Drosophila containing the atypical combination of leucine-rich repeats and immunoglobulin domains, has been implicated in cellular adhesion and related signaling pathways. Deletion studies with Kekkon5 have demonstrated the necessity of both extracellular and intracellular domains for full activity and function.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2008

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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