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A Novel Role of the p53 Tumor Suppressor Pathway in Maintaining Glucose Homeostasis

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Type II diabetes is a disorder that affects the body's ability to produce or utilize insulin, and is characterized by hyperglycemia. The p53 tumor suppressor pathway has been shown to play a role in maintaining glucose homeostasis in a process mediated by Ser18. To better understand insulin resistance, we utilized a loss of p53 function model (phosphorylation mutant p53Ser23Ala) and a model where p53 is hyperactivated (model p44) to further define the role of p53 in insulin sensitivity in vivo. Insulin-mediated Akt activation was analyzed in tissues as a marker for insulin sensitivity. Glucose homeostasis was measured through glucose and insulin tolerance tests. It was found through these mouse models that p53 plays a vital role in regulating glucose homeostasis and insulin sensitivity.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
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  • E-project-042810-124821
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Year
  • 2010
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Date created
  • 2010-04-28
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Last modified
  • 2023-09-20

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