Faculty Advisor

Adams, David S.


Type II diabetes is a disorder that affects the body's ability to produce or utilize insulin, and is characterized by hyperglycemia. The p53 tumor suppressor pathway has been shown to play a role in maintaining glucose homeostasis in a process mediated by Ser18. To better understand insulin resistance, we utilized a loss of p53 function model (phosphorylation mutant p53Ser23Ala) and a model where p53 is hyperactivated (model p44) to further define the role of p53 in insulin sensitivity in vivo. Insulin-mediated Akt activation was analyzed in tissues as a marker for insulin sensitivity. Glucose homeostasis was measured through glucose and insulin tolerance tests. It was found through these mouse models that p53 plays a vital role in regulating glucose homeostasis and insulin sensitivity.


Worcester Polytechnic Institute

Date Accepted

April 2010


Biology and Biotechnology

Project Type

Major Qualifying Project



Advisor Department

Biology and Biotechnology