Faculty Advisor

Adams, David S.

Abstract

Type II diabetes is a disorder that affects the body's ability to produce or utilize insulin, and is characterized by hyperglycemia. The p53 tumor suppressor pathway has been shown to play a role in maintaining glucose homeostasis in a process mediated by Ser18. To better understand insulin resistance, we utilized a loss of p53 function model (phosphorylation mutant p53Ser23Ala) and a model where p53 is hyperactivated (model p44) to further define the role of p53 in insulin sensitivity in vivo. Insulin-mediated Akt activation was analyzed in tissues as a marker for insulin sensitivity. Glucose homeostasis was measured through glucose and insulin tolerance tests. It was found through these mouse models that p53 plays a vital role in regulating glucose homeostasis and insulin sensitivity.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2010

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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