Faculty Advisor

Adams, David S.

Project Center

University of Massachusetts Medical Center


Typically, new neurons migrate randomly out of the RMS into the olfactory bulb. This experiment seeks to view the effect of the release of GABA from active granule cells, which is hypothesized to cause directed migration of neurons in the olfactory bulb. Mouse granule cells were experimentally altered through use of lentiviral vectors delivering genes for ion channel Nachbac. Then, fluorescence microscopy, and the Neurolucida computer module were used to investigate the behavior and distribution of new neurons in the olfactory bulb. Data analysis and experiments in the UMASS Lab show that experimental group TRPA1 works to silence granule cell activity. It is shown that TRPA1-treated GCs work to repel new neurons from the area.


Worcester Polytechnic Institute

Date Accepted

April 2013


Biology and Biotechnology

Project Type

Major Qualifying Project



Advisor Department

Biology and Biotechnology