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Determining the Role of SUB1 in the Repair of DNA Damage in Saccharomyces cerevisiae through a TRP5 Reversion Assay

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Understanding the mechanisms involved in DNA repair is an important step in understanding and possibly controlling numerous human diseases.  Previously the S. cerevisiae gene SUB1 and its human ortholog PC4 have been shown to play an important role in the repair of DNA lesions resulting from oxidative stress. In this project I use a novel TRP5 reversion system to study the mutational changes in sub1 deletion strains. Canavanine mutagenesis was also utilized to test spontaneous mutation frequency.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
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  • E-project-042306-142647
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  • 2016
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  • 2016-10-07
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