Faculty Advisor

Adams, David S.

Abstract

Understanding the mechanisms involved in DNA repair is an important step in understanding and possibly controlling numerous human diseases. Previously the S. cerevisiae gene SUB1 and its human ortholog PC4 have been shown to play an important role in the repair of DNA lesions resulting from oxidative stress. In this project I use a novel TRP5 reversion system to study the mutational changes in sub1 deletion strains. Canavanine mutagenesis was also utilized to test spontaneous mutation frequency.

Publisher

Worcester Polytechnic Institute

Date Accepted

October 2016

Major

Biology and Biotechnology

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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