Faculty Advisor
Adams, David S.
Sponsor
UMass Medical School
Abstract
Understanding the mechanisms involved in DNA repair is an important step in understanding and possibly controlling numerous human diseases. Previously the S. cerevisiae gene SUB1 and its human ortholog PC4 have been shown to play an important role in the repair of DNA lesions resulting from oxidative stress. In this project, I demonstrate that sub1 deletion mutants do not show an increase in UV sensitivity, however, in strains with combinations of other repair genes knocked out, the addition of the sub1 deletion does result in increased UV sensitivity.
Publisher
Worcester Polytechnic Institute
Date Accepted
April 2006
Major
Biology and Biotechnology
Major
Biochemistry
Project Type
Major Qualifying Project
Copyright Statement
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Accessibility
Unrestricted
Advisor Department
Biology and Biotechnology