Faculty Advisor

Adams, David S.

Abstract

Understanding the mechanisms involved in DNA repair is an important step in understanding and possibly controlling numerous human diseases. Previously the S. cerevisiae gene SUB1 and its human ortholog PC4 have been shown to play an important role in the repair of DNA lesions resulting from oxidative stress. In this project, I demonstrate that sub1 deletion mutants do not show an increase in UV sensitivity, however, in strains with combinations of other repair genes knocked out, the addition of the sub1 deletion does result in increased UV sensitivity.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2006

Major

Biology and Biotechnology

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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