Faculty Advisor

Coburn, Jeannine M

Faculty Advisor

Pins, George D

Abstract

Volumetric muscle loss injuries, caused by injuries or burns often result in non-functional scar tissue formation. Current treatments, namely autologous tissue transfer, for such injuries lack the ability to regenerate functional muscle tissue, and often lead to graft failure. Therefore, a more consistent alternative of regeneration is needed. To better treat patients, a fibrin thread-film composite that releases FGF-2 was developed. The scaffold demonstrated functional degradation, cell viability and alignment properties in vitro. In the presence of C2C12 mouse myoblasts, the scaffold provided topographical cues to drive cellular alignment. Additionally, the scaffold released FGF-2 growth factor at a sustained rate.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2017

Major

Biomedical Engineering

Major

Chemical Engineering

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biomedical Engineering

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