Coburn, Jeannine M
Pins, George D
Volumetric muscle loss injuries, caused by injuries or burns often result in non-functional scar tissue formation. Current treatments, namely autologous tissue transfer, for such injuries lack the ability to regenerate functional muscle tissue, and often lead to graft failure. Therefore, a more consistent alternative of regeneration is needed. To better treat patients, a fibrin thread-film composite that releases FGF-2 was developed. The scaffold demonstrated functional degradation, cell viability and alignment properties in vitro. In the presence of C2C12 mouse myoblasts, the scaffold provided topographical cues to drive cellular alignment. Additionally, the scaffold released FGF-2 growth factor at a sustained rate.
Worcester Polytechnic Institute
Major Qualifying Project
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