Challenges facing the production of new pharmaceuticals include the costs associated with recalls from adverse effects and a lack of effective, low-cost model systems for predicting them. Three-dimensional (3D) tissue models offer assays that facilitate faster, more robust pre-clinical screening. These assays require handling multi-sample drug perfusion at cell-viable conditions for long term testing and imaging experiments. Current devices do not achieve these criteria in a cost-effective manner. Initial findings suggest the device achieves the goal of developing a microscope incubator system for drug screening of 3D tissue constructs, presenting a viable diagnostic tool for therapeutic screening.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Connolly, Rachel Marie
• Stratica, Heather
• Kanellias, Marianne

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042617-152841

Advisor

• Pins, George D
• Sullivan, John M.

Year

• 2017

Date created

• 2017-04-26

Resource type

• Major Qualifying Project

Major

• Interdisciplinary
• Biomedical Engineering

Rights statement

• In Copyright

Last modified

• 2021-02-01