Faculty Advisor

Pins, George D

Faculty Advisor

Sullivan, John M.

Abstract

Challenges facing the production of new pharmaceuticals include the costs associated with recalls from adverse effects and a lack of effective, low-cost model systems for predicting them. Three-dimensional (3D) tissue models offer assays that facilitate faster, more robust pre-clinical screening. These assays require handling multi-sample drug perfusion at cell-viable conditions for long term testing and imaging experiments. Current devices do not achieve these criteria in a cost-effective manner. Initial findings suggest the device achieves the goal of developing a microscope incubator system for drug screening of 3D tissue constructs, presenting a viable diagnostic tool for therapeutic screening.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2017

Major

Mechanical Engineering

Major

Biomedical Engineering

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biomedical Engineering

Advisor Department

Mechanical Engineering

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