Pins, George D
Sullivan, John M.
Challenges facing the production of new pharmaceuticals include the costs associated with recalls from adverse effects and a lack of effective, low-cost model systems for predicting them. Three-dimensional (3D) tissue models offer assays that facilitate faster, more robust pre-clinical screening. These assays require handling multi-sample drug perfusion at cell-viable conditions for long term testing and imaging experiments. Current devices do not achieve these criteria in a cost-effective manner. Initial findings suggest the device achieves the goal of developing a microscope incubator system for drug screening of 3D tissue constructs, presenting a viable diagnostic tool for therapeutic screening.
Worcester Polytechnic Institute
Major Qualifying Project
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