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Mathematical Model of Chemotactic Signaling in Sea Urchin Sperm

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We develop a system of ODEs to model the change in calcium concentration in Arbacia punctulata sperm flagella in response to chemotactic signaling. The change in calcium concentration is dependent on membrane voltage, which is in turn dependent on ion channel mechanics. We assume the ion channels can be modeled using Hodgkin-Huxley equations. We numerically solve the system of coupled non-linear ODEs and present the results for membrane voltage and calcium concentration. Experimental data, parameter estimation, and future plans to use this model to gain insight into sperm movement are discussed.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
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  • E-project-042313-193456
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  • 2013
Date created
  • 2013-04-23
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Permanent link to this page: https://digital.wpi.edu/show/nv935444g