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A GAIN OF FUNCTION MUTATION IN THE P/Q TYPE VOLTAGE GATED Ca2+ CHANNEL, UNC-2, STIMULATES ACETYLCHOLINE RELEASE IN CAENORHABDITIS ELEGANS

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zf35 is a mutation in the unc-2 gene of C. elegans that causes a hyperactive phenotype. unc-2 encodes the alpha-1a subunit of a P/Q type calcium channel involved in synaptic transmission in C. elegans. Double mutants were constructed of zf35 and known synaptic transmission mutants egl-30, unc-13, snt-1, and unc-31, to determine how zf35 affects neurotransmitter release. Also, a genetic screen was done to identify mutations that suppress the zf35 phenotype, revealing novel genes in this pathway. We conclude that zf35 mutants have defects in the presynaptic pathway.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
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  • E-project-011309-180004
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Year
  • 2009
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Date created
  • 2009-01-13
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Last modified
  • 2023-09-28

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