Adams, David S.
zf35 is a mutation in the unc-2 gene of C. elegans that causes a hyperactive phenotype. unc-2 encodes the alpha-1a subunit of a P/Q type calcium channel involved in synaptic transmission in C. elegans. Double mutants were constructed of zf35 and known synaptic transmission mutants egl-30, unc-13, snt-1, and unc-31, to determine how zf35 affects neurotransmitter release. Also, a genetic screen was done to identify mutations that suppress the zf35 phenotype, revealing novel genes in this pathway. We conclude that zf35 mutants have defects in the presynaptic pathway.
Worcester Polytechnic Institute
Major Qualifying Project
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Biology and Biotechnology