Faculty Advisor

Adams, David S.

Abstract

zf35 is a mutation in the unc-2 gene of C. elegans that causes a hyperactive phenotype. unc-2 encodes the alpha-1a subunit of a P/Q type calcium channel involved in synaptic transmission in C. elegans. Double mutants were constructed of zf35 and known synaptic transmission mutants egl-30, unc-13, snt-1, and unc-31, to determine how zf35 affects neurotransmitter release. Also, a genetic screen was done to identify mutations that suppress the zf35 phenotype, revealing novel genes in this pathway. We conclude that zf35 mutants have defects in the presynaptic pathway.

Publisher

Worcester Polytechnic Institute

Date Accepted

January 2009

Major

Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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