Faculty Advisor

Adams, David S.

Abstract

A promising therapy for neurodegenerative diseases can be found in neurotrophic factors (NTF's) because of their ability to regenerate and maintain neuronal cell survival. In collaboration with Ceremedix Inc., this MQP investigated the therapeutic potential of small peptides that mimic the NTF ependymin (EPN). The data obtained to date indicate that EPN peptides up-regulate anti-oxidative enzymes in neurons and fibroblast cells using MAPK pathway, and the response was more efficient when peptides were coupled to a blood brain barrier carrier.

Publisher

Worcester Polytechnic Institute

Date Accepted

January 2003

Major

Biotechnology

Project Type

Major Qualifying Project

Accessibility

Restricted-WPI community only

Advisor Department

Biology and Biotechnology

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