Faculty Advisor

Rao, Reeta Prusty

Abstract

A report from the CDC published a “watch list” of antimicrobial resistant “super-bugs”. Fluconazole-resistant Candida was the only fungal species identified as a serious health threat. More recently, C. auris is emerging as a multidrug-resistant fungal pathogen with high mortality rates. C. auris is often resistant to all classes of antifungal drugs and tends to occur in hospitalized patients with the same risk factors as infection by any Candida spp. This has prompted the CDC to issue a call-to-action to “better understand, contain and stop the spread of this drug-resistant fungus”. Here we use C. elegans as a model host to measure the virulence of clinical isolates of C. auris, C. tropicalis, C. dubliniensis, C. lusitaniae, and C. krusei as compared to a reference strain C. albicans.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2018

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Restricted-WPI community only

Advisor Department

Biology and Biotechnology

Available for download on Sunday, April 25, 2021

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