Faculty Advisor

Rulfs, Jill

Abstract

Adenoviruses are commonly used as gene vectors because of their low level of morbidity and ability to infect both dividing and non-dividing cells. Adenoviral expression systems in which a target gene is delivered to mammalian cells are commercially available. Here, I used one such system to individually express the genes of all dengue-2 virus proteins in an adenovirus, with the ultimate goal of infecting of primary dendritic cells. Through my work, I developed an optimized plan for future use of this system.

Publisher

Worcester Polytechnic Institute

Date Accepted

January 2004

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Restricted-WPI community only

Advisor Department

Biology and Biotechnology

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