Faculty Advisor

Camesano, Terri A.

Faculty Advisor

McGimpsey, William Grant

Abstract

Amphiphilic polymers act as surfactants for oil-in-water emulsions. There is no doubt that emulsions promise a better means of delivery as far as rate and quantity are concerned, but the key to controlling these factors lies in the polymeric surfactant holding the emulsion together. Currently, release of medications in vivo is an uncontrolled and unsustainable process. Nanocapsules containing drug are potential means of drug delivery that can be moderated with the use of biocompatible oils dispersed as tiny droplets in water. The goal of this project was to continue past research using polysaccharide as surfactants in emulsions intended for drug delivery. The most stable emulsions were obtained using 10 grams per liter of hydrophobically modified dextran (DexP) and Miglyol (triglyceride) oil. This emulsion also offered gradual, regular drug release rates and resisted aggregation after lyophilization. Research was performed in collaboration with WPI and ENSIC.

Publisher

Worcester Polytechnic Institute

Date Accepted

January 2004

Major

Chemistry

Major

Chemical Engineering

Project Type

Major Qualifying Project

Accessibility

Restricted-WPI community only

Advisor Department

Chemical Engineering

Advisor Department

Chemistry and Biochemistry

Advisor Program

Chemical Engineering

Advisor Program

Chemistry and Biochemistry

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