Camesano, Terri A.
McGimpsey, William Grant
Amphiphilic polymers act as surfactants for oil-in-water emulsions. There is no doubt that emulsions promise a better means of delivery as far as rate and quantity are concerned, but the key to controlling these factors lies in the polymeric surfactant holding the emulsion together. Currently, release of medications in vivo is an uncontrolled and unsustainable process. Nanocapsules containing drug are potential means of drug delivery that can be moderated with the use of biocompatible oils dispersed as tiny droplets in water. The goal of this project was to continue past research using polysaccharide as surfactants in emulsions intended for drug delivery. The most stable emulsions were obtained using 10 grams per liter of hydrophobically modified dextran (DexP) and Miglyol (triglyceride) oil. This emulsion also offered gradual, regular drug release rates and resisted aggregation after lyophilization. Research was performed in collaboration with WPI and ENSIC.
Worcester Polytechnic Institute
Major Qualifying Project
Access to this report is limited to members of the WPI community. Please contact a project advisor or their department to request access
Restricted-WPI community only
Chemistry and Biochemistry