Faculty Advisor

Ryder, Elizabeth F.

Abstract

Amyotrophic lateral sclerosis is a fatal paralytic disorder characterized by premature motor neuron death; a hypermetabolic state has also been observed. Western blotting was used to characterize the expression of PGC-1alpha and PPAR-delta, two metabolic regulators, in tissue of G85R ALS mice and wild-type littermates at different development time points. Initial results indicate that PGC-1 alpha may be expressed at higher levels in skeletal muscle of young ALS mice, suggesting PGC-1alpha's potential involvement in the hypermetabolism evident in ALS.

Publisher

Worcester Polytechnic Institute

Date Accepted

January 2006

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Restricted-WPI community only

Advisor Department

Biology and Biotechnology

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