Faculty Advisor
Ryder, Elizabeth F.
Sponsor
U.Mass Medical Center
Abstract
Amyotrophic lateral sclerosis is a fatal paralytic disorder characterized by premature motor neuron death; a hypermetabolic state has also been observed. Western blotting was used to characterize the expression of PGC-1alpha and PPAR-delta, two metabolic regulators, in tissue of G85R ALS mice and wild-type littermates at different development time points. Initial results indicate that PGC-1 alpha may be expressed at higher levels in skeletal muscle of young ALS mice, suggesting PGC-1alpha's potential involvement in the hypermetabolism evident in ALS.
Publisher
Worcester Polytechnic Institute
Date Accepted
January 2006
Major
Biology and Biotechnology
Project Type
Major Qualifying Project
Copyright Statement
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Accessibility
Restricted-WPI community only
Advisor Department
Biology and Biotechnology
Advisor Program
Biology and Biotechnology