Faculty Advisor

Ryder, Elizabeth F.

Abstract

Bone cell development can be studied using various cell lines in vitro. Analysis of a previously conducted microarray experiment showed a class of "neuronal" genes expressed in an early stage on bone development. These genes include ULIP, protease-nexin 1, and RAS p21 protein activator. They were observed to be expressed in successive stages of osteoblast development in C2C12, MC3T3, and MLO-Y4 cell lines using real-time quantitative PCR. The expression of these genes loosely correlated with changes in cell morphology.

Publisher

Worcester Polytechnic Institute

Date Accepted

January 2004

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Restricted-WPI community only

Advisor Department

Biology and Biotechnology

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