Faculty Advisor

DiBiasio, David

Faculty Advisor

Kohles, Sean S.

Abstract

Brief Design evaluation of a bioreactor for growth of chondrocytes on polymer matrices was conducted. Varying compositions of polyglycolic acid and poly-l-lactic acid were studied to determine an optimal matrix construction. A media usage period was determined. DNA and cell numbers as well as extracellular matrix components were measured at higher concentrations within the bioreactor than for static controls. Design modifications were implemented to eliminate contamination. The results support the use of bioreactors for cartilage growth over static culture.

Publisher

Worcester Polytechnic Institute

Date Accepted

January 1999

Major

Biomedical Engineering

Project Type

Major Qualifying Project

Accessibility

Restricted-WPI community only

Advisor Department

Chemical Engineering

Advisor Department

Biomedical Engineering

Advisor Program

Chemical Engineering

Advisor Program

Biomedical Engineering

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