Adams, David S.
Brief episodes of ischemia (preconditioning) protect the myocardium from contractile dysfunction induced by subsequent episodes of ischemia. However, it is not known whether the hypertrophied myocardium can be preconditioned. This study was designed to investigate whether hearts with compensated (C-POH) and decompensated pressure overload hypertrophy (D-POH) can be preconditioned by short periods of ischemia. The data indicated that ischemic and hypoxic preconditioning enhance the recovery of function following global ischemia in the isolated rat heart, and that adenosine is not the sole mediator of pre-conditioning.
Worcester Polytechnic Institute
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Biology and Biotechnology