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Chronic Adolescent Exposure to THC Alters Cognition, Metabolite Levels, and Inflammatory Profile in Rats

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Cannabis is a prevalent drug that is commonly used both as a therapeutic agent and abused as an illicit drug. Despite the widespread use, little is known about the pharmacokinetics of its main psychoactive component, Δ9-tetrahydrocannabinol (THC), or how it affects the body. In order to understand the long-term consequences of adolescent exposure to THC, adolescent rats were administered with the drug and assessed during adolescence and adulthood for cognitive, developmental, and neurochemical changes. These results suggest lasting cognitive deficits, impairment in the glutamatergic system, and a neuroinflammatory profile, and emphasize the need for further research.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
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  • E-project-060117-165851
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  • 2017
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  • 2017-06-01
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