Faculty Advisor

Heilman, Destin

Center

University of Massachusetts Medical Center

Abstract

Cannabis is a prevalent drug that is commonly used both as a therapeutic agent and abused as an illicit drug. Despite the widespread use, little is known about the pharmacokinetics of its main psychoactive component, Δ9-tetrahydrocannabinol (THC), or how it affects the body. In order to understand the long-term consequences of adolescent exposure to THC, adolescent rats were administered with the drug and assessed during adolescence and adulthood for cognitive, developmental, and neurochemical changes. These results suggest lasting cognitive deficits, impairment in the glutamatergic system, and a neuroinflammatory profile, and emphasize the need for further research.

Publisher

Worcester Polytechnic Institute

Date Accepted

June 2017

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Restricted-WPI community only

Advisor Department

Chemistry and Biochemistry

Project Center

University of Massachusetts Medical Center

Available for download on Saturday, June 01, 2019

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