University of Massachusetts Medical Center
University of Massachusetts Medical School
Cannabis is a prevalent drug that is commonly used both as a therapeutic agent and abused as an illicit drug. Despite the widespread use, little is known about the pharmacokinetics of its main psychoactive component, Δ9-tetrahydrocannabinol (THC), or how it affects the body. In order to understand the long-term consequences of adolescent exposure to THC, adolescent rats were administered with the drug and assessed during adolescence and adulthood for cognitive, developmental, and neurochemical changes. These results suggest lasting cognitive deficits, impairment in the glutamatergic system, and a neuroinflammatory profile, and emphasize the need for further research.
Worcester Polytechnic Institute
Major Qualifying Project
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Chemistry and Biochemistry
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