Krushkal, Julia S.
Computational analysis was performed on amino acid sequences of poxviruses and herpesviruses to show relationships to human complement regulators, factor H and C4 binding protein -chain (C4bp). Sequence alignments and phylogenetic trees have demonstrated that all viral proteins studied are similar to both complement regulators. Poxviruses showed a higher similarity to C4bp. A number of individual domains of the viral sequences show similarity to the functional regions of human complement regulators, explaining their role in modulating the host immune response.
Worcester Polytechnic Institute
Major Qualifying Project
Access to this report is limited to members of the WPI community. Please contact a project advisor or their department to request access
Restricted-WPI community only
Biology and Biotechnology