Faculty Advisor

Krushkal, Julia S.

Abstract

Computational analysis was performed on amino acid sequences of poxviruses and herpesviruses to show relationships to human complement regulators, factor H and C4 binding protein -chain (C4bp). Sequence alignments and phylogenetic trees have demonstrated that all viral proteins studied are similar to both complement regulators. Poxviruses showed a higher similarity to C4bp. A number of individual domains of the viral sequences show similarity to the functional regions of human complement regulators, explaining their role in modulating the host immune response.

Publisher

Worcester Polytechnic Institute

Date Accepted

January 2001

Major

Biotechnology

Project Type

Major Qualifying Project

Accessibility

Restricted-WPI community only

Advisor Department

Biology and Biotechnology

Advisor Program

Biology and Biotechnology

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