Faculty Advisor

Gibson, Daniel Gilbert

Abstract

Ependymin is a vertebrate neurotrophic factor. Its presence has been confirmed in the horseshoe crab, Limulus polyphemus, (Barroso 1999) but its role in this animal is unknown. Experiments were performed to determine if ependymin is involved in limb regeneration for Limulus. Legs were removed from horseshoe crabs in various stages of development and the subjects were treated with either rabbit anti-ependymin (SHEILA) or a control substance. The larval and post-larval subjects did not exhibit a great deal of difference between the treatment and control groups. The two- and three-year juvenile subjects, however, indicated that anti-ependymin treatment is correlated with slower regeneration.

Publisher

Worcester Polytechnic Institute

Date Accepted

January 2000

Major

Biology

Project Type

Major Qualifying Project

Accessibility

Restricted-WPI community only

Advisor Department

Biology and Biotechnology

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