Gibson, Daniel Gilbert
Ependymin is a vertebrate neurotrophic factor. Its presence has been confirmed in the horseshoe crab, Limulus polyphemus, (Barroso 1999) but its role in this animal is unknown. Experiments were performed to determine if ependymin is involved in limb regeneration for Limulus. Legs were removed from horseshoe crabs in various stages of development and the subjects were treated with either rabbit anti-ependymin (SHEILA) or a control substance. The larval and post-larval subjects did not exhibit a great deal of difference between the treatment and control groups. The two- and three-year juvenile subjects, however, indicated that anti-ependymin treatment is correlated with slower regeneration.
Worcester Polytechnic Institute
Major Qualifying Project
Access to this report is limited to members of the WPI community. Please contact a project advisor or their department to request access
Restricted-WPI community only
Biology and Biotechnology