Concern over the safety of BPA in plastic products has lead to its substitution with related bisphenols BPF and BPS, though the safety of these alternatives is unknown. Using fluorescence microscopy and Western blots, we examined cellular stress responses in several human cell lines following treatment with bisphenols. We find that BPA and BPF cause stress granule formation, likely via activation of the PKR kinase pathway. This work has important implications for the continued use of bisphenols in plastics.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Hoppe, Megan Theresa
• Friend, Chandler
• Wu, Jingyi

Contributors

• Kedersha, Nancy

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042518-124022

Advisor

• Farny, Natalie

Year

• 2018

Date created

• 2018-04-25

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright