Faculty Advisor

Adams, David S.

Abstract

Hematopoietic stem cells (HSCs) are primitive adult progenitor cells capable of differentiation into multiple blood cell lineages. In the past several years, there have been a significant number of publications suggesting that adult stem cells have a 'plasticity' that defies the central dogma of unidirectional cellular development. To promote the potential neuronal differentiation in HSCs, an optimal culturing and conditioning regimen was developed, and then examined for efficacy using both fresh and thawed HSCs derived from human umbilical cord blood. It was determined that neuronal-like cells can form from both fresh and thawed HSC-enriched populations when cultured in an optimized neuronal microenvironment.

Publisher

Worcester Polytechnic Institute

Date Accepted

January 2001

Major

Biotechnology

Project Type

Major Qualifying Project

Accessibility

Restricted-WPI community only

Advisor Department

Biology and Biotechnology

Advisor Program

Biology and Biotechnology

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