University of Massachusetts Medical Center
UMass Medical School
Histones can undergo modifications, which regulate the accessibility of DNA. Modifications such as acetylation alter the epigenetic landscape, which regulates the expression of genes. Epigenetic regulations have been linked to important developmental stages of cardiovascular development. Because of their large clutch sizes, and transparent embryos, zebrafish are a useful for studying the effect of compounds believed to be epigenetic regulators. The aim of this project was to screen a library of small molecule compounds on zebrafish, for their effect on cardiovascular development. The library was screened on zebrafish, and thereafter analyzed by in vitro and in vivo assays. It was determined that six of these compounds had varying inhibitory properties on HDAC enzymes.
Worcester Polytechnic Institute
Major Qualifying Project
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Chemistry and Biochemistry
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