In this project the effects of a cannabinoid, Ajulemic Acid (AjA), on different types of rheumatoid tissues were studied. Cultured synovial cells, synovial fluid cells and peripheral blood mononucleocytes, were treated with AjA prior to stimulation with TNF-. The results showed a marked decrease in the cytokines Interleukin-6 and Interleukin-8. As both IL-6 and IL-8 play a part in the pathogenesis of rheumatoid arthritis, reduction of their secreted levels could serve as an effective treatment for the disease.
Worcester Polytechnic Institute
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Biology and Biotechnology