Faculty Advisor

Rulfs, Jill

Abstract

In this project the effects of a cannabinoid, Ajulemic Acid (AjA), on different types of rheumatoid tissues were studied. Cultured synovial cells, synovial fluid cells and peripheral blood mononucleocytes, were treated with AjA prior to stimulation with TNF-. The results showed a marked decrease in the cytokines Interleukin-6 and Interleukin-8. As both IL-6 and IL-8 play a part in the pathogenesis of rheumatoid arthritis, reduction of their secreted levels could serve as an effective treatment for the disease.

Publisher

Worcester Polytechnic Institute

Date Accepted

January 2002

Major

Biotechnology

Project Type

Major Qualifying Project

Accessibility

Restricted-WPI community only

Advisor Department

Biology and Biotechnology

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