Krushkal, Julia S.
Ryder, Elizabeth F.
In this project, we used two data mining tools, CBA and WEKA, to search for genetic polymorphisms that affect two human diseases, autosomal recessive spinal muscular atrophy (SMA) and bilateral optic neuropathy (LHON). We modified WEKA to be able to mine genetic data. Our results provided a number of association rules, which identified important genetic variants and phenotypic factors affecting the disease state and severity.
Worcester Polytechnic Institute
Major Qualifying Project
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Biology and Biotechnology