Faculty Advisor
Tuzel, Erkan
Faculty Advisor
Vidali, Luis
Abstract
Correlation analysis is a tool commonly used to obtain information about the dynamics of biofilaments such as actin and microtubules in cells. This approach is particularly useful when individual identification of filaments is difficult in vivo. The goal of this project is to develop a coarse-grained model of dynamic actin filaments using Brownian dynamics simu- lations, and to validate correlation analysis as a viable technique to measure the dynamics, and determine its range of applicability. Particular focus is on the dependence on the density of filaments, as well as polymerization and depolymerization.
Publisher
Worcester Polytechnic Institute
Date Accepted
April 2013
Major
Physics
Project Type
Major Qualifying Project
Copyright Statement
All authors have granted to WPI a nonexclusive royalty-free license to distribute copies of the work, subject to other agreements. Copyright is held by the author or authors, with all rights reserved, unless otherwise noted.
Accessibility
Unrestricted
Advisor Department
Physics
Advisor Department
Biology and Biotechnology