Correlation analysis is a tool commonly used to obtain information about the dynamics of biofilaments such as actin and microtubules in cells. This approach is particularly useful when individual identification of filaments is difficult in vivo. The goal of this project is to develop a coarse-grained model of dynamic actin filaments using Brownian dynamics simu- lations, and to validate correlation analysis as a viable technique to measure the dynamics, and determine its range of applicability. Particular focus is on the dependence on the density of filaments, as well as polymerization and depolymerization.
Worcester Polytechnic Institute
Major Qualifying Project
Biology and Biotechnology