Faculty Advisor

Tuzel, Erkan

Faculty Advisor

Vidali, Luis

Abstract

Correlation analysis is a tool commonly used to obtain information about the dynamics of biofilaments such as actin and microtubules in cells. This approach is particularly useful when individual identification of filaments is difficult in vivo. The goal of this project is to develop a coarse-grained model of dynamic actin filaments using Brownian dynamics simu- lations, and to validate correlation analysis as a viable technique to measure the dynamics, and determine its range of applicability. Particular focus is on the dependence on the density of filaments, as well as polymerization and depolymerization.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2013

Major

Physics

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Physics

Advisor Department

Biology and Biotechnology

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