Faculty Advisor

Politz, Samuel M.


Mutations in the C. elegans gene srf-6 result in the constitutive display of a surface antigen normally displayed only in the L1 developmental stage. To determine the location of these mutations, an extensive DNA sequence analysis of a candidate gene region, previously shown to partially rescue srf-6, was undertaken for each of 8 identified mutants. An additional mutant, produced by transposon insertion, was stabilized by back-crossing. Finally, a transcriptional analysis was performed to determine the exon/intron pattern of the candidate gene.


Worcester Polytechnic Institute

Date Accepted

January 2003


Biology and Biotechnology

Project Type

Major Qualifying Project


Restricted-WPI community only

Advisor Department

Biology and Biotechnology

Advisor Program

Biology and Biotechnology