Politz, Samuel M.
Nematode surface proteins share structural properties with vertebrate mucins. During infection, parasitic nematodes may change these surface proteins to escape host immune responses. Studies of the Caenorhabditis elegans srf-6 gene led to discovery of a mucin-like coding sequence called F41G3.10 The amino acid sequence encoded is similar to that of a know nematode surface protein. An RNA transcript of F41G3.10 was detected in wild type C. elegans RNA. Developmentally synchronous cultures will be studied to determine when F41G3.10 is expressed.
Worcester Polytechnic Institute
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Biology and Biotechnology