Adams, David S.
Neuroprotective peptides NMI-9236 and NMI-8933 are drugs designed for emergency stroke treatment. Prior research indicated that the neurotrophic peptides upregulate Activator Protein-1, a transcription factor implicated in the neuroprotective function of the drugs. The purpose of this major qualifying project was to determine whether this upregulated particle is functional, i.e., capable of transcriptional trans-activation. The results indicate that the upregulated AP-1 is functional. These results contribute to the ongoing effort to elucidate the drugs' molecular mechanisms of action.
Worcester Polytechnic Institute
Major Qualifying Project
Access to this report is limited to members of the WPI community. Please contact a project advisor or their department to request access
Restricted-WPI community only
Biology and Biotechnology