Faculty Advisor

Adams, David S.

Abstract

Neuroprotective peptides NMI-9236 and NMI-8933 are drugs designed for emergency stroke treatment. Prior research indicated that the neurotrophic peptides upregulate Activator Protein-1, a transcription factor implicated in the neuroprotective function of the drugs. The purpose of this major qualifying project was to determine whether this upregulated particle is functional, i.e., capable of transcriptional trans-activation. The results indicate that the upregulated AP-1 is functional. These results contribute to the ongoing effort to elucidate the drugs' molecular mechanisms of action.

Publisher

Worcester Polytechnic Institute

Date Accepted

January 1999

Major

Biotechnology

Project Type

Major Qualifying Project

Accessibility

Restricted-WPI community only

Advisor Department

Biology and Biotechnology

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