Tufts School of Veterinary Medicine
Opiates have been used for centuries to treat pain. The use of opiates on horses produces dysphoric side effects. The [mu]-receptor has been sequenced in five organisms. An equine cDNA library was created from horse brain. The use of rt-PCR to construct a probe of or clone directly the [mu]-receptor was ultimately unsuccessful. Once cloned, further experiments to elucidate the signal transduction pathway, distribution of receptor throughout the CNS, and binding kinetics may lead to more effective analgesics.
Worcester Polytechnic Institute
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Biology and Biotechnology