Faculty Advisor

Adams, David S.

Abstract

Paramyxoviruses are enveloped, negative-stranded RNA viruses that include such pathogens as Measles virus, Mumps virus, Parainfluenza virus and Newcastle disease virus (NDV), the focus of this Major Qualifying Project. Experimenting with co-expression of viral proteins HN and F from NDV and from other paramyxoviruses enabled us to hypothesize that heterologous co-expression of HN and F proteins result in down-regulation of HN expression. We conclude that this down-regulation is due to the misfolding of HN and its subsequent degradation in the proteasome.

Publisher

Worcester Polytechnic Institute

Date Accepted

January 1999

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Restricted-WPI community only

Advisor Department

Biology and Biotechnology

Advisor Program

Biology and Biotechnology

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